26例甲型H1N1流感确诊病例临床特征及治疗情况分析

Analysis on the clinical feature and treatment of 26 patients infected with influenza A (HIN1)

目的:探讨甲型H1N1流行性感冒(流感)病例临床特点及处置方法。方法:回顾性分析我院2009年5月15日～6月8日收治住院的26例甲型H1N1流感确诊病例临床资料,明确诊断后隔离,积极给予中医个体化治疗及磷酸奥司他韦胶囊等抗病毒治疗,并与同期26例上呼吸道感染病例作对比分析。结果:治疗组13～49岁发病率显著高于对照组(P<0.01),50岁以上年龄发病率显著低于对照组(P<0.01)。治疗组临床症状中乏力发生率显著高于对照组(P<0.01),体温升高发生率明显高于对照组(P<0.05)。治疗组肝功能异常1例,心肌酶异常1例。治疗组痊愈出院25例,住院时间2～7 d,平均5.6 d。治疗后H1N1流感病毒阴转时间3～7 d,平均4.5 d。1例53岁重症患者持续高热合并肺气肿和既往肺结核病史,呼吸衰竭,转院后死亡。对照组26例全部治愈,无死亡病例。两组患者家属及医护人员均无接触感染。结论:甲型H1N1流感是一种传染性强的急性传染病,青年人容易受感染,有一定的并发症,中西医结合治疗是降低病死率的有效方法。

Objective： To explore the clinical feature and treatment of the patients infected with influenza A（HIN1）.Methods： The clinical data of 26 hospitalized patients infected with influenza A（H1N1） from May 15 to June 8 in 2009 were analyzed retrospectively,then isolation after treatment,and gave them individual treatment of traditional Chinese medicine and Oseltamivir Phosphate Capsules,and compared with 26 patients with acute upper respiratory infection.Results： The patients with age 13-49 in the treatment group,morbidity was higher than that of the control group,with age ≥50 was lower than that of the control group（all P〈0.01）;lack of strength and high body temperature were significantly more common（P〈0.01,P〈0.05）.1 case with abnormal liver function and 1 case with abnormal myocardium enzyme in the treatment group.Cured 25 cases in the treatment group,2-7 days（average 5.6 days） in the hospital.The negative-transfer time of H1N1 in the treatment group was 3-7 days（average 4.5 days）,and 1 case of patient（age 53） died of emphysema pulmonum,tu-berculosis and respiratory failure after turn to the other hospital.There was no death in the control group.The doctors and nurses and family numbers of the patients had no contact infection.Conclusion： The clinical symptoms of the patients in-fected with influenza A（H1N1） are slightly more severe than those of upper respiratory patients,youth are vulnerable,it′s an effective method that the combination of traditional Chinese medicine and western medicine to reduce mortality.