复发性口腔溃疡与幽门螺杆菌所致消化性溃疡的相关性研究

Relationship between recurrent aphthous ulcer and peptic ulcer induced by Helicobacter pylori

目的探讨复发性口腔溃疡(recurrent aphthous ulcer,RAU)与幽门螺杆菌(Helicobacter pylori,HP)及消化性溃疡的相关性。方法采用聚合酶链反应(PCR)法分别检测128例RAU患者及128例健康对照组口腔HP阳性率情况,13C呼气试验检测54例HP阳性的RAU患者抗HP的三联药物治疗组和常规抗炎治疗组的治疗效果。结果 128例RAU患者和128例健康人群HP的阳性率分别为42.2%和15.9%(P<0.01),128例RAU患者和128例健康人群中,伴有胃肠道疾病的和未伴有消化性溃疡的比例分别为25.0%和9.4%(P<0.05)。54例HP阳性的RAU患者中,抗HP治疗和常规治疗的RAU有效率分别为81.5%,51.9%(P<0.05)。结论口腔中HP及消化性溃疡均与RAU的发病有某种相关。HP感染与RAU的发病率之间有一定关联,RAU患者较健康人群消化性溃疡患病率高,抗HP药物治疗更有利于RAU的愈合。

Objective To investigate the association of recurrent aphthous ulcer（RAU） with Helicobacter pylori（Hp） infection and peptic ulcer disease.Methods Saliva were collected from 128 patients with RAU and 128 healthy volunteers were detected for Hp with PCR.Results The positive rates of Hp differed significantly between RAU patients and healthy volunteers（42.2% vs 15.9%,P0.001）.In RAU patients and healthy volunteers,25.0% and 9.4% were identified to have peptic ulcer（P0.01）.In the 54 RAU patients with HP,the effective rates are 81.5% and 51.9%（P0.05）.Conclusion Oral Helicobacter pylori and peptic ulcer diseases might have some relationships with RAU.