急性脑卒中患者高敏感C反应蛋白水平测定的临床意义

The Clinical Significance of Determination of High-sensitivity C-reactive Protein Levels in Acute Stroke Patients

目的讨论急性脑卒中患者高敏感c反应蛋白（hs—CRP）水平与病情严重程度的关系及其临床价值。方法选择明确诊断的我院住院的急性脑卒中患者106例，其中脑梗死68例，脑出血38例。、按临床神经功能缺损程度评分标准分。重型〉30分，其12例，普通型≤30分，共94例。对照组为同期住院的非脑卒中患者60例，两组资料在年龄，性别及其它身体状况方面对比无显著性差异，具有对比性，皆入院48h内取全血20川测定高敏感C反应蛋白的含量水平。hs—CRP正常值为O．068～8．2mg／L，〉8．2mg／L为阳性。结果脑卒中组hs—CRP阳性率49．1％，与对照组相比具有显著性差异（P〈0．01）；脑卒中组hs-CRP平均值（6．45±2．81）mg／L，对照组hs—CRP平均值（2．14±1．03）mg／L，两组相比有显著性差异（P〈0.01）；脑卒中组重型hs—CRP平均值（16．42±3．17）mg／L，普通型为（5．26±2．54）mg／L，两组相比差异有显著性（P〈O．01）。结论急性脑卒中患者hs—CRP水平与病情严重程度呈正相关，hs—CRP越高，病情越严重，同时预后越差。hs—CRP水平作为脑卒中病情与预后的危险预测因素．值得临床关注。

Objective To discuss the relationship between high-sensitivity c-reactive protein （hs-CRP） levels in acute stroke patients and severity and its clinical value. Methods To select the clear diagnosis in hospitalized patients with acute stroke of 106 cases with cerebral infarction 68 cases and intracerebral hemorrhage 38 cases. According to the clinical neurologic scoring criteria, heavy type 〉 30, a total of 12 cases, ordinary type ≤ 30, a total of 94 cases. 60 hospitalized patients with non-acute stroke for the same period were as the control group, the datas on age, gender, and other physical conditions had no significant difference by comparison, in both groups the patients were hospitalized within 48 h, 20/zl whole blood were taken to determine the hs-CRP levels. The normal value of hs-CRP was 0.068 - 8.2 mg/L, 〉 8.2 mg/L as positive. Results In stroke group the positive rate ofhs-CRP was 49.1%, compared to the control group, there was significant difference （P〈0.01）; in stroke group the average value ofhs-CRP was （6.45± 2.81） mg/L, in control group the average value of hs-CRP was （2.14 ±1.03） mg/L, there was significant difference between the two groups （P〈0.01）; in stroke group the average value of hs-CRP in heavy type was （16.42 ± 3.17） mg/L, ordinary type was （5.26 ± 2.54） mg/L, there was significant difference between the two groups （P〈0.01）. Conclusion Hs-CRP in acute stroke patients has positive correlation with the severity levels, the higher the hs-CRP, the more serious condition, while the poorer the prognosis. Hs-CRP levels as the risk predictors of stroke severity and prognosis deserve clinical attention.