摘要
目的:为安全生产补硒保健食品和保障食品安全提供科学参考依据。方法:本试验旨在用保健食品常见的硒强化剂亚硒酸钠对小鼠进行不同剂量灌胃,通过急性和蓄积性毒性试验,系统研究硒对小鼠生长性能,组织病理变化,血常规、血液生化指标等的影响,建立小鼠硒中毒的动物模型。结果:急性毒性试验表明:小鼠经口LD50为3.86mg/kg;蓄积性毒性试验表明:亚硒酸钠对小鼠有弱蓄积性。
Kun Ming mice were taken as animal models and were intragastricly administrated wtih Sodium Selenium-containing health foods for the acute and accumulative toxicity experiment.By the systematic research of the effects of selenium on the growth,pathological change,blood biochemical and routine indexes of the animals.Result showed that the LD50 was 3.86 mg/kg and selenium was weak accumulative toxicity to mice.This research provided some scientific evidence and reference for the production of non-polluted meat products and the food supervision department.
出处
《现代食品科技》
EI
CAS
2010年第10期1043-1046,1080,共5页
Modern Food Science and Technology
基金
四川省"十五"攻关课题(05NG003-017)
关键词
亚硒酸钠
急性毒性
蓄积性毒性
食品安全
sodium selenium
acute toxicity
accumulative toxicity
food safety