三维适形放疗联合TP方案化疗治疗食管癌术后纵隔淋巴结转移的临床观察

Clinical Observation of Three Dimensional Conformal Radiation Therapy Combined with TP Regimen Chemotherapy for Mediastinal Lymph Node Metastasis After Operation of Esophagus Cancer

目的观察三维适形放疗(3DCRT)联合TP方案化疗治疗食管癌术后纵隔淋巴结转移的疗效。方法 84例食管癌术后纵隔淋巴结转移患者随机分为两组,单纯3DCRT组(A组)和3DCRT联合TP方案化疗组(B组),每组42例。A组患者仅接受3DCRT,B组患者接受3DCRT和TP方案化疗。分别评价两组的疗效和毒副反应。结果 A、B组1、2、3年生存率分别为28.6%、19.0%、7.1%和50.0%、26.2%、9.5%;两组有效率分别为76.2%、92.8%(P<0.05)。B组毒副反应较A组重,但经对症处理后均可缓解。结论 3DCRT联合TP方案化疗治疗食管癌术后纵隔淋巴结转移患者可提高其生存率和有效率。

Objective To observe the curative effect of three dimensional conformal radiation therapy（3DCRT） plus TP regimen chemotherapy in the treatment of mediastinal lymph node metastasis after operation of esophagus cancer.Methods Eighty four cases with mediastinal lymph node metastasis after operation of esophagus cancer were divided randomly into two groups：42 cases were treated with 3DCRT（named A group） ;another 42 cases with 3DCRT combined with TP regimen chemotherapy（named B group）.The curative effect and toxicities of the two groups were evaluated respectively.Results The 1-,2-,3-year survival rates of A group and B group were 28.6%,19.0%,7.1% and 50.0%,26.2%,9.5% respectively.The overall response rates of A group and B group were 76.2% and 92.8%（P 0.05）.The toxicities of B group which could be tolerated were higher than those of A group.Conclusion 3DCRT combined with TP regimen chemotherapy can improve the survival rate and overall response rate of patients with mediastinal lymph node metastasis after operation of esophagus cancer.