心房颤动60例抗凝治疗分析

The analysis of anticoagulant treatment to atrial fibrillation in 60 cases

目的:对心房颤动60例患者抗凝治疗进行分析。方法:回顾性分析本院2007年2～10月住院患者中的心房颤动患者60例,分为心血管病房40例及其他病房20例两组,均采用华法林抗凝治疗。结果:60例患者经过治疗之后,有效51例(85%),无效9例(15%),有效率为85%。根据患者服用华法林后第3～4天INR值上升的速度和幅度,判断患者对华法林的敏感性,分为不敏感、敏感、很敏感,根据敏感性以1mg增减剂量,不敏感者加量1mg,很敏感者减量1mg。本组60例患者中很敏感者15例,平均体重为(49.85±8.06)kg;敏感者32例,平均体重为(58.97±6.58)kg;不敏感者13例,平均体重为(81.19±7.77)kg。体重小的人群敏感性高,体重大的人群敏感性低。结论:华法林价格便宜,抗凝效果肯定,只要掌握好其药理特性,还是目前最好的选择。

Objective：To 60 patients for anticoagulant therapy of atrial fibrillation were analyzed.Methods：A retrospective analysis of hospital 2 October 2007 hospitalized patients with atrial fibrillation in 60 patients,divided into 40 cases of cardiovascular wards and other wards in 20 cases the two groups were treated with warfarin.Results：60 patients after treat ment,effective in 51 cases（85%）,9 cases（15%）,the effective rate of 85%.According to the patients taking warfarin 3 to 4 days after the INR values have increased the speed and magnitude,to determine the sensitivity of warfarin in patients divided into non-sensitive,sensitive,very sensitive,according to increase or decrease the sensitivity to 1 mg dose,were not sensitive to dosage 1 mg,were very sensitive to reduction of 1 mg.The group of 60 patients,15 cases are sensitive to the average body weight（49.85±8.06） kg;sensitivity in 32 patients,average weight（58.97±6.58） kg;not sensitive to 13 patients,average weight（81.19±7.77） kg.Weight of small populations with high sensitivity and low weight of the sensitivity of a large crowd.Conclusion：Cheap warfarin,anticoagulant effects are,as long as the master of its pharmacological properties,or the best choice.