应用高频超声评价动脉粥样硬化血管内皮功能

Evaluation of vascular endothelial function by high frequency ultrasonography in atherosclerotic rabbits

目的:应用高频超声评价动脉粥样硬化(A S)兔血管内皮功能。方法:35只兔随机分为两组:A组,对照组(10只);B组,A S模型组(25只);超声检测不同时期各组兔的血管内皮依赖性舒张功能(EDD)和血管内皮非依赖性舒张功能(NEDD),并进行了相关的血脂测定及病理检查。结果:随着动脉粥样硬化的进展,血脂逐渐升高,EDD和NEDD先后出现不同程度损伤且逐渐加重,皆伴随不同程度的病理改变。结论:高频超声是评价A S血管内皮功能的良好方法。

Objective：To assess the vascular endothelial function of atherosclerostic rabbits by high frequency sonography.Methods：Thirty five rabbits were randomly divided to control group（A group）and atherosclerosis group（B group）.Endothelial dependent dilation（EDD） and non-endothelial dependent dilation（NEDD） were measured by using high resolution sonography at different time points.Results：With atherosclerosis progress and blood fat increase,EDD and NEDD showed damage to a different extent and became worse progressively.Conclusion：Ultrasonography is a useful method to evaluate the vascular endothelium function.