期刊文献+

DVd方案治疗多发性骨髓瘤26例疗效观察 被引量:3

下载PDF
导出
摘要 目的进一步提高多发性骨髓瘤(MM)的治疗效果。方法将46例MM患者随机分为观察组26例及对照组20例,分别采用DVd(脂质体阿霉素、长春新碱、地塞米松)及MP(马法兰、泼尼松)方案进行化疗,每月1个疗程(4d)。4个疗程结束后判定疗效,比较不良反应发生情况。结果观察组及对照组总有效率分别为76.9%、45.0%(P<0.05)。两组治疗后血红蛋白水平、IgA及IgG均明显改善,治疗组改善程度明显优于对照组,P均<0.05。观察组骨髓抑制发生率明显低于对照组(P<0.05);两组其他不良反应发生率及感染发生率比较无显著差异。结论 DVd方案治疗多发性骨髓瘤近期疗效较好,不良反应小,优于MP方案。
出处 《山东医药》 CAS 北大核心 2010年第39期92-93,共2页 Shandong Medical Journal
  • 相关文献

参考文献6

  • 1陈灏珠.实用内科学[M]10版[M].北京:人民卫生出版社,1999.672-674.
  • 2Oken MM,Harrihgton DP,Abramson N,et al.Comparison of melphalan and prednisone with vincyistine,carmustime meiphalan,cyclophospham and prednisone in the treatment of multiple myeloma.Results of Eastern Cooperative Oncology Study E2479[J].Cancer,1997,79(8):1561-1567.
  • 3Alexanian R,Haut A,Khan AU,et al.Treatment for multiple myeloma.Combination chemotherapy with different melphalan dose regimens[J].JAMA,1969,208(9):1680-1685.
  • 4Chee CE,Kumar S,Larson DR,et al.The importance of bone marrow examination in determining complete response to therapy in patients with multiple myeloma[J].Blood,2009,114(13):2617-2618.
  • 5Kepty D,Chow L,Anderson K,et al.Cancer drug manual[M].2th ed.British Columbia:BC Cancer Agency,Division of Pharmacy,1994:455.
  • 6Zervas K,Dimopoulos MA,Hatzicharissi E,et al.Primary treatment of multiple myeloma with thalidomide,vincristine,liposomal doxorubicin and dexamehasone(T-VAD doxil):a phase II multicenter study[J].Ann Oncol,2004,15(1):134-138.

共引文献48

同被引文献29

  • 1Greer JP, Foerster J, Lukens JN. Wintrobe's clinical hematology [ M ]. 11 th ed. Philadelphia: Lippincott Williams&Wilkins,2004 : 2583 - 2636.
  • 2Jayasundar R, Shah T, Vaishya S, Singh VP, Sarkar C. In vivo and in vitro MR spectroscopic profile of central neurocytomas[ J]. J Magn Reson Imaging,2003,17(2) :256 -260.
  • 3Rajkumar SV, Jacobus S, Callander NS, Fonseca R, Vesole DH, Williams ME, Abonour R, Siegel DS, Katz M, Greipp PR, Eastern Cooperative Oneology Group. Lenalidomiide plus highdose dex- amethasone versus lenalidomiide plus low - dose dexamethasone as initial therapy for newly diagnosed multiple myeloma:au openlabel randomized controlled trial[ J]. Lancet Oncol,2010,11 ( 1 ) :29 - 37.
  • 4Oken MM, Harrington DP, Abramson N, Kyle RA, Knospe W, Glick JH. Comparison of melphalan and prednisone with vincyis- tine,carmustime meiphalan,eyclophospham and prednisone in the treatment of multiple myeloma. Results of Eastern Cooperative On- cologv Study E2 479 [ J]. Cancer. 1997.79 ( 8 ) :1561 - 1567.
  • 5Blade J, Samson D, Reece D. Creteria for evaluating disease re- sponse and progession in patients with multiple myeloma treated by high- dose therapy and haemopeietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant [ J ]. Br J Haemaol, 1998, 102 ( 10 ) : 1115 - 1123,.
  • 6San Miguel JF, Schlag R, Khuageva NK, Dimopoulos MA, Shpil- berg O, Kropff M, Spieka I, Petrucci MT, Palumbo A, Samoilova OS, Dmoszynska A, Abdulkadyrov KM, Schots R, Jiang B, Ma- teos MV, Anderson KC, Esseltine DL, Liu K, Cakana A, van de Velde H, Richardson PG; VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple my- eloma[ J]. N Engl J Meal,2008,359(9) :906 -917.
  • 7Hulin C, Facon T, Rodon P, Pegourie B, Benboubker L, Doyen C, Dib M, Guillerm G, SalIes B, Esehard JP, Lenain P, Casas- sus P, Azais I, Decaux O, Garderet L, Mathiot C, Fontan J, Lafon I, Virion JM, Moreau P. Efficacy of melphalan and predni- sone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01 /01 trial [ J]. J Clin On- col,2009,27(22) :3664-3670.
  • 8周韶红,陈佩,许毅.黄振翘血液病临证经验撷英[M].上海:上海中医药大学出版社,2009:209-210.
  • 9Senapati SB,Mishra SS,Dhir MK,et al.A case of multiple myeloma presenting as scalp swelling with intracranial extension[J].J Neurosci Rural Pract,2013,4(4):445-448.
  • 10Livingood M,Newman SA.An unusual presentation of perforating metastatic calcino siscutis[J].Skinmed,2013,11(5):314-315.

引证文献3

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部