N-取代苯并咪唑酯类衍生物的合成及表征

The synthesis and characterization of derivatives of N-benzimidazolylacetates

目的合成苯并咪唑酯及其衍生物,并对其合成方法进行改进研究。方法以邻苯二胺为起始原料合成了苯并咪唑-2-甲酸乙酯(1)和苯并咪唑-2-乙酸乙酯(2),再以丙酮为溶剂,分别与乙酰氯,苯甲酰氯和二茂铁甲酰氯常温反应3 h。结果合成了N-取代苯并咪唑-2-甲酸乙酯酰胺衍生物(1a-1c),N-取代苯并咪唑-2-乙酸乙酯酰胺衍生物(2a-2c),并通过IR,1H NMR,MS和元素分析确定了分子结构。结论合成方法简便、易行、产率高,为进一步形成配合物奠定了良好基础。

Aim To make improvement on the synthetic method of benzimidazolyacetates and their corresponding derivatives.Methods Synthesizing ethyl 2-benzimidazolecarboxylate（1） and ethyl 2-benzimidazolyacetate（2） from readily available materials o-phenylendiamine,and then making both of them reacted with acetyl chloride,benzoyl chloride and ferrocenylcarbonyl chloride respectively at room temperature for 3h in acetone.Results Derivatives of N-ethyl 2-benzimidazolecarboxylate amide（1a-1c） and N-ethyl 2-benzimidazolyacetate amide（2a-2c） were obtained with a good yield,and the molecular structures were confirmed by IR,1HNMR,MS and elemental analysis.Conclusion The synthetic method has the advantages of high yield and ease of preparation,which laid a solid foundation for the further synthesis of coordination compounds.