聚N-(2-羟丙基)甲基丙烯酰胺-美他沙酮前药的合成与表征

Synthesis and characterization of PHPMA-Met macromolecule prodrug

目的研究聚N-(2-羟丙基)甲基丙烯酰胺-美他沙酮(PHPMA-Met)前药的合成方法。方法以偶氮二异丁腈(AIBN)为引发剂,通过自由基反应,聚合得到PHPMA,进而以氯乙酰氯为连接基,与Met反应,合成了PHPMA-Met,并对产物进行了元素、红外、差示扫描量热分析鉴定和表征。结果 Met在前药中的含量大于15%。结论该制备方法简单,条件温和,具有很好的应用前景。

Aim To report a method for synthesis of poly N-（2-hydroxypropyl） methacrylamide-Met（PHPMA-Met）macromolecule prodrug.Methods With AIBN as initiator,Polymerization of PHPMA is synthesized with monomer HPMA by radical reaction;then PHPMA-Met is synthesized thorugh using the reaction of PHPMA and Met by chloroacetyl chloride as connect the base.The products are characteriized by FTIR,elementary analysis and DSC.Results The content of Met in the prodrug is more than 15%.Conclusion The macromolecular prodrug preparation method is simple,mild,and has high yields with good prospect of application.