阿托品对氢化可的松快速作用的影响

Effects of Atropine on Rapid Effects of Hydrocortisone 21 Hemisuccinate

在离体灌流的牛蛙交感神经节上，氢化可的松一方面通过Ｎ受体介导，快速抑制Ｂ细胞的快兴奋性突触后电位（ｆＥＰＳＰ），引起Ｂ细胞突触传递的阻断。氢化可的松又同时通过Ｍ受体介导，快速增强Ｂ细胞的慢兴奋性突触后电位（ｓＥＰＳＰ），提高Ｂ细胞的兴奋性，使重复放电增加。用阿托品阻断Ｂ细胞上Ｍ受体，可以压抑氢化可的松对ｓＥＰＳＰ的增强效应，增加氢化可的松对Ｂ细胞突触传递的快速抑制作用。

Effects of atropine on rapid modulation of synaptic responses of B neurons by hydrocortisone 21-hemisuccinate(F suc) were investigated. The results were as follows: F suc inhibited fast excitatory postsynaptic potential (fEPSP)by modulating N receptor and blocked the synaptic transmission of B neurons in the bullfrog sympathetic ganglia in vitro. Meanwhile, F suc also potentiated slow excitatory postsynaptic potential (sEPSP)by modulating M receptor and raised excitability of B neurons. It may promote repetitive discharges on B neurons. Atropine blocked M receptor and depressed sEPSP. Therefore atropine may potentiate rapid inhibitory effects on synaptic transmission of B neurons by applying F suc.