增强MRA及依达拉奉在单纯疱疹病毒性脑炎中的临床研究

Clinical studies on Gd-DTPA-enhancement MR angiography and edaravone applied to herpes simplex encephalitis

目的探讨磁显葡胺增强磁共振血管成像(简称Gd-DTPA-MRA)表现及相关MRI改变对中、重度单纯疱疹病毒性脑炎(HSE)诊断价值及依达拉奉的治疗应用。方法回顾性分析53例经脑脊液常规,脑电图,颅脑CT等检查临床怀疑的中、重度HSE患者进行MRI及增强MRA检查,48例确诊,确诊患者随机分为两组,实验组应用依达拉奉配合传统抗病毒等治疗,对照组22例行传统抗病毒等治疗。结果 MRA显示全脑动脉及细小分支和静脉系统,48例单纯疱疹病毒性脑炎增强磁共振血管成像表现正常。实验组临床治疗的显效率明显高于对照组,存在差异(P<0.05)。结论临床可应用增强MRA技术对怀疑HSE的患者进行确诊,依达拉奉对治疗HSE具有明显的效果。

OBJECTIVE To investigate the clinical value of manifestations of Gd-DTPA enhancement MR angiography（Gd-DTPA-MRA）and correlations with MR imaging in the diagnosis and the therepeutic effect of edaravone on moderte and severe herpes simplex encephalitis（HSE）.METHODS 53 patients were suspected of moderate and severe HSE after examined with Cerebrospinal fluid,EET and CT.48 patients were confirmed after Gd-DTPA-MRA using.Confirmed patients were divided into exerimental（conventional therapy combined with edaraxone）and control（conventional therapy only）groups randomLy.RESULTS Whole brain cerebral arteries as well as their small branches and cerebral vein system could be displayed on Gd-DTPA-MRA and manifestation be negatively 48 patients in HSE.The experimental group gota higher excellence than control group（P〈0.01）.CONCLUSION Gd-DTPA-MRA can be used to confirm the moderate and severe HSE in clinic;edaravone has an obvious therapeutic effect on HSE.