某些疾病患者血及尿γ-谷氨酰转移酶的变化

Changes of Serum and Urine γ GT in Some Diseases

对肾病综合征、金属镉中毒、烧伤及肺癌患者血、尿γ谷氨酰转移酶（γＧＴ）进行同时测定，并与正常人比较。结果：肾病综合征患者（３０例）血清γＧＴ降低，Ｐ＜００５，尿γＧＴ升高，Ｐ＜００１；镉中毒患者（１３例）血清γＧＴ升高，尿γＧＴ升高，Ｐ＜００１，对这两组病人同时检测尿蛋白，与尿γＧＴ成正相关。烧伤患者（２１例）血清γＧＴ下降，Ｐ＜００１，尿γＧＴ无明显变化，Ｐ＞００５；肺癌患者（３１例）血、尿γＧＴ无明显变化，Ｐ＞００５。以上实验表明血、尿γＧＴ在不同疾病变化不同，测定肝胆系统以外疾病的血、尿γＧＴ水平亦有一定的临床意义。

It is demonstrated that serum γ GT increases in hepatobiliary diseases and the diseases of other systems. Urine γ GT also increases in certain kidney diseases. The clinical significance of the decreasing in serum and urine γ GT has not been reported. The author performed the determination of serum and urine γ GT in nephrotic syndrome, cadmium toxicosis, burn patients and lung cancers. In comparison with normal body, the results were as follow: in 30 nephrotic syndromes, serum γ GT decreased (P<0 01);in the meantime, the urine proteins were also determined in the same specimens and urine proteins were positively relative to the urine γ GT.In 21 burn patients, serum γ GT decreased (P<0 01), but there were no obvious changes in urine γ GT(P>0 05) In 31 lung cancers, no obvious changes in serum and urine γ GT(P>0 05). All the results indicate that the serum and urine γ GT vary with diseases.