银杏达莫治疗突发性耳聋的临床疗效观察

Preliminary clinical study of application of EGB761 in treatment of sudden deafness

目的对银杏达莫注射液治疗突发性耳聋的疗效进行临床观察。方法将87例(114耳)突发性耳聋患者按就诊顺序分成银杏达莫组即实验组44例(59耳)和对照组43例(55耳)。实验组用含银杏叶提取物和双嘧达莫的银杏达莫注射液治疗,对照组用复方丹参治疗;另外两组同时加用地塞米松、ATP、肌苷和B族维生素等药物及高压氧治疗。两组在治疗前和治疗后4 d开始每3 d用纯音电测听测试患者听力。结果经治疗后,实验组44例(59耳)中痊愈20例(27耳),显效14例(18耳),有效5例(7耳),无效5例(7耳),治愈率为45.3%,有效率为88.4%;对照组43例(55耳)中痊愈8例(12耳),显效8例(13耳),有效14例(15耳),无效9例(15耳),治愈率为20.7%,有效率为72.1%,两组统计学处理差异有显著性(P<0.05)。结论银杏达莫治疗突发性耳聋的临床疗效肯定,按该组剂量未发现有明显副作用。

Objective To investigate the effect of application of EGB761（xingdin） on sudden deafness.Methods 87 patients（114 ears） with sudden deafness were randomly divided into EGB761（xingdin） group（n=59 ears）and control group（n=55 ears）.Besides intravenous administration of EGB761（xingdin）,another treatments in EGB761（xingdin）group were the same as that in control group including hyperbaric oxygen,vasodilator,energy preparation such as ATP and dexam-ethasone（DXM）.Results The hearing threshold was recovery in 27 ears,significant improved in 18 ears,improved in 7 ears and notchanged in 7 ears after tretatment in EGB761（xingdin） group;in control group,the hearing threshold was recovered in 12 ears,significant improved in 13 ears,improved in 15 ears and no hearing changed in 15 ears.There was significant difference between EGB761 group and control group（P〈0.05）.Conclusion The application of EGB761（xingdin） combined with DXM can significantly improve the effect of treatment on sudden deafness and EGB761（xingdin） may enhance the recovery rate in the patients with sudden deafness,which was much higher than that treated by the traditional methods.