相同MAC浓度的地氟醚和异氟醚对脑电图的影响

The effects of equivalent effective concentration of desflurane and isoflurane on EEG

目的比较相同ＭＡＣ浓度的地氟醚和异氟醚对脑电图的影响。方法２０例２０～５０岁，ＡＳＡⅠ～Ⅱ级择期手术的病人，均不用术前药。麻醉诱导以静脉异丙酚２ｍｇ／ｋｇ，琥珀胆碱２ｍｇ／ｋｇ快速气管插管，单纯吸入地氟醚或异氟醚维持麻醉。控制呼吸，维持呼气末二氧化碳分压（ＰＥＴＣＯ２）在４７～６０ｋＰａ。以ＴＯＦ监测肌松，维持Ｔ４／Ｔ１＜２５％。以双导联方式监测脑电变化，观察呼气末麻醉药浓度在０５、０８、１０、１３和１５ＭＡＣ时的脑电边缘频率（ＳＥＦ）和双谱指数（ＢＩ）的改变。结果随ＭＡＣ的增加ＳＥＦ和ＢＩ逐渐减小，呈负性线性相关关系（ｒ分别为－０９５和－０９９，Ｐ＜００１），两组间ＳＥＦ和ＢＩ无显著性差异（Ｐ＞００５）。结论地氟醚对脑电图的影响与异氟醚相似；ＥＥＧ对监测麻醉深度有一定指导意义。

Objective To compare the effects of desflurane and isoflurane on EEG Methods 20 ASA grade Ⅰ～Ⅱ,aged 20～50 years,unpremedicated adult patients,undergoing elective surgery were randomly divided into two groups:desflurane(n=10)and isoflurane group(n=10).Anesthesia was induced with propofol 2mg/kg and succinylcholine 2mg/kg intravenously and maintained with inhalation anesthetics.After intubation patients were ventilated mechanically to maintain P ET CO 2 between 4 7 and 6 0kPa.The TOF ratio of T 4/T 1 was maintained less than 25% throughout anesthesia.Two channels EEG monitor was applied.End-tidal concentration was adjusted at 0 5、0 8、1 0、1 3 and 1 5MAC in sequence,was maintained for 10 min before SEF and BI were recorded.Results There were negative remarkable correlation between either SEF or BI and MAC in both groups( r =-0 95 and -0 99, P <0 01).There was no significant difference between two groups in EEG.Conclusions The EEG may be useful in evaluating anesthesia depth.The effects of desflurane and isoflurane on EEG were similar at equivalent effective concentration. [