褶合光谱法测定复方地塞米松滴眼液的含量

Application of convolution spectrometry method for determination of compound dexamethasone sodium phosphate eye drops

目的：建立不经分离同时测定地塞米松磷酸钠及干扰组分尼泊金乙酯含量的测定方法。方法：以蒸馏水为空白，采用褶合光谱法。结果：平均回收率为１００８％，９９３９％；ＲＳＤ为１００％，０６１％。结论：本法方便准确，适用于紫外吸收有干扰的多组分制剂的常规分析。

OBJECTIVE: To simultaneous determine the main-component dexamethasone sodium phosphate and the interfering-component ethylparaben in compound dexamethasone sodium phosphate eye drops without separation. METHODS: A convolution spectrometry method has been applied. RESULTS: The average recoveris and relative standard deviation were 100.8%,10%;9939%,061%,respectively. CONCLUSION: This method is convenient,accuracy and suitable for routine analysis of multicomponent preparation which has interference in ultraviolet spectrum.