两种化疗方案治疗肺癌的疗效比较

Two regimens for chemotherapy of lung cancer in comparison

目的：对比观察环磷酰胺、西艾克、阿霉素、顺铂（ＣＶＡＤ）与环磷酰胺、卡铂、足叶乙甙（ＣＣＥ）两方案治疗肺癌的疗效。方法：应用ＣＶＡＤ与ＣＣＥ两种联合化疗方案治疗５６例肺癌，观察疗效和毒性反应，并采用两样本比较的秩和检验或χ２检验。结果：ＣＶＡＤ方案和ＣＣＥ方案对肺癌的总有效率分别为６５％及４４％（Ｐ＞０．０５）。其中，对小细胞肺癌的有效数分别为８／９及５／７；对非小细胞肺癌的有效率分别为５５％及３３％（Ｐ＞０．０５）。ＣＶＡＤ方案对于初治和复治肺癌患者的有效率与ＣＣＥ方案差异均无显著性（Ｐ＞０．０５）；而恶心、呕吐、脱发、静脉炎等发生率ＣＶＡＤ方案高于ＣＣＥ方案（Ｐ＜０．０５～Ｐ＜０．０１）。结论：两方案对于初治肺癌患者均可选用。

Objective:To observe the clinical effect of CVAD and CCE regimen in treatment of lung cancer.Methods:56 patients with lung cancer were treated with CVAD and CCE regimen.Results:The effective rate was 65% for CVAD and 44% for CCE in lung cancer.The effective rate for CVAD and CCE were 8/9 and 5/7 respectively in SCLC,and 55% and 33% respectively in NSCLC( P >0.05).The difference in effective rate in treatment of new and treated cases was not significant between these 2 regimens( P >0.05).However,nausea,vomiting,alopecia and phlebitis in CVAD regimen were more serious than in CCE regimen( P <0.05～ P < 0.01 ).Conclusions:Both CVAD and CCE regimen can be used for treatment of lung cancer.