中国居民2型糖尿病下肢血管病变危险因素的Meta分析研究

Risk Factors of Peripheral Artery Disease in Type 2 Diabetes Patients in China:A Meta-analysis

目的通过文献检索,获取密切相关文献,探讨我国2型糖尿病患者下肢血管病变(PVD)的危险因素。方法利用文献检索方法检索相关文献,共纳入文献15篇,采用RevMan4.2.2统计软件进行Meta分析研究。结果影响2型糖尿病患者发生PVD的重要因素有年龄、病程、糖化血红蛋白(HbA1c)、总胆固醇(TC)、收缩压、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、空腹血糖(FPG),有统计学意义(P<0.01);而体质指数(BMI)、舒张压、高密度脂蛋白胆固醇(HDL-C)、餐后2h血糖(P2BG)则对PVD是否发病的影响无统计学意义(P>0.05)。结论初步确定年龄、病程、HbA1c、TC、收缩压、LDL-C、TG、FPG是2型糖尿病患者发生PVD的重要危险因素,为临床上PVD的早检测、早诊断提供依据。

Objective Through literature retrieval to obtain the intimately related literature,and study the risk factors of peripheral artery disease （PVD） in patients with type 2 diabetes （T2DM）.Methods Totally 15 papers related were selected by using literature retrieval,Rev Man 4.2.2 software was used for meta-analysis.Results The key risk factors such as age,course of disease,glycosylated hemoglobin,（HbA1c）,total cholesterol （TC）,systolic blood pressure,lower density lipoprotein-cholesterol （LDL-C）,triglyceride （TG）,and fasting blood glucose （FPG） （P〈0.01） affected the happening of PVD in T2DM patients,but the factors of body mass index,diastolic blood pressure,high density lipoprotein-cholesterol,and 2-h postprandial blood glucose did not statistically influence PVD（P〈0.05）.Conclusion The age course of disease,HbA1c,TC,diastolic blood pressure,LDL-C,TG,and FPG are primarily determined as the important risk factors of PVD in T2DM,which can provide a basis for early detection and diagnosis of PVD in clinic.