摘要
目的：探讨乳腺癌患者血清中胰岛素样生长因子-1 （IGF-1）的含量及癌组织血管内皮生长因子（VEGF）的表达在乳腺癌中的临床意义. 方法：应用双位点免疫放射测定法（IRMA）对不同TNM分期的60例乳腺癌患者术前术后血清IGF-1进行检测,应用SP免疫组化法检测各组乳腺癌组织VEGF的表达,15例乳腺良性病患者设为正常对照. 结果：乳腺癌患者术前血清IGF-1水平明显高于术后水平及正常对照,乳腺癌组织VEGF表达率较正常对照组高,差异均有显著性意义（均P〈0.05）,不同病理分期的乳腺癌血清IGF-1水平与癌组织VEGF阳性表达间差异有显著性意义（P〈0.05）. 结论：乳腺癌患者血清IGF-1水平与乳腺癌临床病理分期呈正相关,与癌组织VEGF表达密切相关,提示IGF-1和VEGF可能参与了乳腺癌的发生发展过程,有望作为乳腺癌诊治的重要检测指标.
Objective To detect the serum insulin-like growth factor 1 （IGF-1） level and tissue VEGF expression in patients with breast cancer and investigate its clinical significance. Methods The serum IGF-1 level was determined by immunoradiometrie assay （IRMA） and the expression of tissue VEGF was detected by SP immunohistochemical assay in 60 pre-and post-operative cases of breast cancer （based on TNM staging）. Fifteen normat subjects were taken as control group. Results The serum IGF- 1 level before operation was higher than that in control group and postoperation. VEGF expression rate was higher in tumor tissue than normal tissue, and the difference was significant （ P 〈0.05）. In patients with different pathological stages the serum IGF- 1 level and tumor VEGF expression was statistically significant （ P 〈0.05）. Conclusion The serum IGF-1 level and tumor VEGF expression in different stages of breast eaneer was proportional to the severity of disease, so the serum IGF-1 level and VEGF expression may be an indicator of cancer occurrence and progression. Therefore, they may become an important diagnostic marker in breast cancer.
关键词
胰岛素样生长因子-1
血管内皮生长因子
乳腺癌
insulin-like growth factor-1
vascular endothelial growth factor
breast cancer
