摘要
目的：探讨糖皮质激素在IgA肾病治疗中的价值,为其临床干预治疗提供依据.方法：对应用糖皮质激素治疗的51例IgA肾病患者的临床资料进行回顾性分析.结果：51例IgA肾病患者肾组织活检后平均随访（14.6±8.2）个月;治疗前尿蛋白量为（2.28±1.51）g/24h治疗后则降到（0.85±0.78）g/24h（P=0.000）;治疗前平均肾小球滤过率为（84.14±41.74）ml/min,治疗后为（86.13±40.21） ml/min （P〈0.05）.同时不同蛋白尿程度、有无高血压、治疗前有无肾功能受损及不同的肾脏病理表现的患者激素治疗后尿蛋白水平均显著降低.结论：应用糖皮质激素治疗IgA肾病能显著降低患者的尿蛋白,保护肾功能.
Objective：To explore the value of glucocorticoid in the treatment of IgA nephropathy and to provide basis for clinical intervention treatment. Methods Clinical data of 51 cases of IgA nephropathy treated with glucocorticoid were retro-spectlvely analyzed. Results 51patients were followed up for （14.6±8.2） months after biopsy of renal tissue. Urine protein decreased from （2.28±1.81）g/24h to （0.85±0.78）g/24h （P=0. 000） after treatment with glucocorticoid. Glomerular filtration rate increased from （84. 145：41.74）ml/min to （86.13±40.21） ml/min （ P 〈0.05） after treatment with glucocorticoid. The urine protein level in the patients with different urine protein, hypertension, renal injury and pathological feature significantly decreased . Conclusion Glucocorticoid can significantly decrease urine protein and protect renal function.
出处
《医学信息（下旬刊）》
2010年第11期109-109,111,共2页
Medical information
