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高血压患者血白细胞介素-6白细胞介素-18水平变化研究 被引量:2

高血压患者血白细胞介素-6白细胞介素-18水平变化研究
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摘要 目的:探讨高血压病患者血清白细胞介素6(IL-6)和白细胞介素18(IL-18)水平变化的临床意义。方法:采用酶联免疫吸附试验(ELISA)法检测72例高血压病患者血清IL-6 IL-18水平,同时设70例正常对照。结果:高血压病患者血清IL-6、IL-18水平均显著高于正常对照组(t=4.51 10.07,均P<0.01),IL-6与IL-18呈正相关(r=0.684,P<0.05)。结论:血清高IL-6、IL-18水平可能是高血压病发的重要因素之一。 Objective:To explore the clinical significance of changes of changes of serum IL- 6 and IL- 18 levels in Hypertensive patients. Methods serum IL- 6 and IL- 18 levels were determined with ELISA in 72 hypertensive patients and 70 controls Results In hypertensive patients, the serum IL- 6 and IL- 18 levels were significantly higher than those in the controls (t = 4.51 10.07 all P 〈 0.01), and the changes of IL - 6 were positively related to IL- 18(r= 0.684,, P 〈 0.05)Conclusion Maybe high serum IL-6 and IL- 18 levels were one of the main pathophysio- logic features in hypertension
出处 《内蒙古中医药》 2010年第19期84-84,共1页 Inner Mongolia Journal of Traditional Chinese Medicine
关键词 高血压病 白细胞介素6 白细胞介素18 Hypertension interleukin 6 interleulkin 18
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参考文献5

  • 1Ishimitsu T,,Ono H,Minami J, et al.Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders[].Pharmacology and Therapeutics.2006
  • 2Vilarrasa N,Vendrell J,Maravall J,et al.IL-18:relationship with anthropometry,body composition parameters,leptin and arterial hypertension[].Hormone and Metabolic Research.2006
  • 3Hirano T.Interleukin 6 and its receptor: ten years later[].International Reviews of Immunology.1998
  • 4Hoshino T,Kato S,Oka N,et al.Pulmonary inflammation and emphysema:role of the cytokines IL-18and IL-13[].American Journal of Respiratory and Critical Care Medicine.2007
  • 5Ishimitsu T,Ysukada K,Minami J,et al.Variation of human adrenomedullin gene and its relation to cardiovascular diseases[].Hypertension Research.2003

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