慢性疲劳综合征大鼠造模两种方法比较

Chronicity weary synthesis drafts the big mouse to make mold two method comparison

目的：探讨桶束缚法与架束缚法致大鼠慢性疲劳造模的比较.方法： 30只雄性Wistar大鼠随机分为桶束缚组,架束缚组与对照组,每组各10只,采用慢性束缚的方式确立大鼠慢性疲劳综合征模型,观察各组大鼠的力竭游泳实验.结果：桶束缚组比较架束缚组大鼠的行为学指标更接近慢性疲劳状态,且死亡量较少.结论：确立较为理想的慢性疲劳动物模型架束缚法优于桶束缚法.

Objective： Discusses the barrel fetter law to send the big mouse chronicity with the fetter law to make the mold wearily the comparison. Methods：30 male Wistar big mice divide into the barrel fetter group stochastically,puts up the fetter group and the control group,each group of each 10,use the chronic fetter the way to establish the big mouse chronicity weary synthesis to draft the model, observes each group of big mouse＇s strength to use up the swimming experiment. Results： The barrel fetter group compares the fetter group big mouse＇s behavior study target closer ehronieity state of fatigue,also the death quantity are few. Conclusion ：Establishes the more ideal chronic weary animal model support fetter law to surpass the barrel fetter law.