利妥昔单抗的罕见不良反应

Rituximab-induced rare adverse reactions

利妥昔单抗是一种人/鼠嵌合型抗CD20单克隆抗体,主要应用于非霍奇金淋巴瘤的治疗。利妥昔单抗的常见不良反应为急性输液反应,其他严重不良反应罕见。本文概述了利妥昔单抗相关的罕见不良反应如急性呼吸窘迫综合征、弥漫性肺泡出血、心律失常、心源性猝死、慢性心功能不全、进行性多灶性白质脑病、肿瘤溶解综合征、细胞因子释放综合征等,以及不良反应可能的发病机制、临床表现和处理措施,旨在为临床安全应用利妥昔单抗提供参考。

Rituximab is a human/mouse chimeric anti-CD20 monoclonal antibody mainly used in the treatment of non-Hodgkin＇s lymphomas.The most common rituximab-caused adverse reaction is acute infusion-related reactions and serious adverse reactions are rare.This article reviews the rituximab-induced rare adverse reactions,such as acute respiratory distress syndrome,diffuse alveolar hemorrhage,cardiac arrhythmia,sudden cardiac death,chronic heart failure,progressive multifocal leukoencephalopathy,tumor lysis syndrome,and cytokine release syndrome,as well as the possible pathogenesis,clinical features,and the management in order to provide references for safe rituximab use in clinical practice.