摘要
1例81岁女性患者,因下颌骨左侧骨化纤维瘤伴面颊部蜂窝组织炎,使用头孢他啶3.0g加入5%葡萄糖注射液250mL,2次/d静脉滴注;0.5%奥硝唑100mL,1次/d静脉滴注。当晚患者出现不自主的头部及右手颤抖。实验室和心电图均未见明显异常;头颅CT检查,除轻度脑萎缩外无其他异常。给予地西泮10mg肌内注射;口服多巴丝肼片0.125mg,3次/d。3d后患者症状未见缓解。考虑震颤为头孢他啶引起的锥体外系反应。遂停用头孢他啶,改用头孢唑啉,其他用药不变。患者震颤症状消失,左侧面颊部蜂窝组织炎明显消退。
A 81-year-old woman received an IV infusion of ceftazidime 3.0 g dissolved in 250 mL of 5% glucose,twice daily,and an IV infusion of 0.5% ornidazole 100 mL once daily,respectively,for ossifying fibroma with facial cellulitis in her left lower jaw bone.In that evening the patient developed involuntary tremor of head and right hand.The laboratory examination and electrocardiogram showed no marked change.No abnormal changes were found on her cranial CT examination except slight encephalatrophy.She was given IM diazepam 10 mg and oral levodopa-benserazine 0.125 mg,thrice daily.Three days later,her symptoms did not improved.Her tremor was considered to be ceftazidime-induced extrapyramidal reactions.Ceftazidime was discontinued and changed to cefazolin.Her other medicines remained unchanged.Her left facial cellulitis improved and tremor disappeared.
出处
《药物不良反应杂志》
2010年第5期356-357,共2页
Adverse Drug Reactions Journal
关键词
头孢他啶
不良反应
锥体外系反应
震颤
ceftazidime
adverse reactions
extrapyramidal reactions
tremor
