摘要
1例71岁男性患者,因高血压服用尼群地平10～20mg/d治疗。5年后出现牙龈增生,停用尼群地平,换用卡托普利治疗,2周后症状明显缓解。但卡托普利致频繁干咳,再次使用尼群地平,牙龈增生再次出现,且逐渐加重,并影响咬合。给予对症治疗无效,再次停用尼群地平,1周后牙龈肿胀缓解,2周后不适感消失,牙龈增生逐渐消退。
A 71-year-old man received nitrendipine 10-20 mg daily for the treatment of hypertension.Five years later,he developed gingival hyperplasia.Nitrendipine was stopped and switched to captopril.After 2 weeks,the symptoms of gingival hyperplasia markedly relieved.Subsequently,he received nitrendipine again due to frequent cough caused by captopril,and then gingival hyperplasia appeared again.The symptoms were aggravated gradually and progressed to affect occlusion.The symptomatic treatment was ineffective.Nitrendipine was discontinued again.One week later,gingival hyperplasia relieved and,2 weeks later,his discomfort disappeared and gingival hyperplasia subsided gradually.
出处
《药物不良反应杂志》
2010年第5期368-369,共2页
Adverse Drug Reactions Journal
关键词
尼群地平
不良反应
牙龈增生
nitrendipine
adverse reactions
gingival hyperplasia
