脑胶质瘤细胞IL-6自分泌环路的研究

Study of IL 6 Autocrine Circle in Humun Glioma cells

应用重组白细胞介素－６（ｒＩＬ－６）及白细胞介素－６单抗（ＩＬ－６ＭｃＡｂ）分别处理脑胶质瘤细胞株ＳＨＧ－４４及４例脑胶质瘤患者体外培养的人脑胶质瘤细胞。结果显示，ｒＩＬ－６能刺激ＳＨＧ－４４细胞及人脑胶质瘤细胞的增殖，且均呈剂量依赖关系。表明人脑胶质瘤中亦存在白细胞介素－６（ＩＬ－６）自分泌环路，这种自分泌环路的存在可能参与维持脑胶质瘤的恶性增殖。

Human glioma cells line SHG 44 and fresh isolated human glioma cells were mixed with recombinant interleukin 6 (rIL 6) and IL 6McAb and were cultured in vitro Results showed rIL 6 could stimulate the proliferation of SHG 44 cells and human glioma cells,but IL 6McAb could suppress the proliferation of them The stimulation or suppression were in a dose dependant way This indicate that human gliomas also exist the IL 6 autocrine circle and this kind of IL 6 autocrine circle may play an important role in sustaining the malignant proliferation of human gliomas