用正交设计法优选湿疹乳剂的基质组成及工艺

Optimization of matrix composition and technology for eczema emulsion by orthogonal design method

目的：优选湿疹乳剂的基质组成及工艺。方法：针对影响乳剂稳定性的因素，用正交设计法，以油相、乳化剂和乳化温度为可变因素，选用Ｌ９（３４）表进行实验。结果：最优的基质组成及工艺是：硬脂酸７．０ｇ，液体石蜡４．０ｍｌ，凡士林０．６ｇ，单硬脂酸甘油酯３．４ｇ，三乙醇胺０．６５ｍｌ，吐温８０２．０ｇ，乳化温度９０℃。

OBJECTIVE:To optimizate matrix composition and technology for eczema emulsion.METHODS:According to the factors that affect the stability of eczema emulsion, orthogonal design method was used,oil phase,emulsifiers and emulsify temperature were selected as variable factors and table L 9(3 4) was used to do experiment.RESULTS:The optimun matrix composition and technology were: stearic acid 7.0 g,liquid paraffin 4.0 ml,vaselin 0.6 g,glyceryl monostearate 3.4 g,triethanolamine 0.6 g,Tween 80 2.0 g,emulsify temperature 90℃.CONCLUSIONS:The eczema emulsion prepared by this kind of composition and technology accord with the stipulation of Chinese Pharmacopoeia(1995).