紫外分光光度法测定米诺地尔酊的含量

Determination of minoxidil in minoxidil tincture by ultraviolet spectrophotometry

目的：用紫外分光光度法测米诺地尔酊中米诺地尔的含量，为该药提供质量控制方法。方法：紫外分光光度法。结果：米诺地尔浓度在０．５～６μｇ·ｍｌ－１范围内吸收度与溶液浓度呈线性关系（ｒ＝０．９９９９，ｎ＝５），回收率为１００．４％，ＲＳＤ为０．１０％（ｎ＝５）。结论：该法能作为米诺地尔酊含量测定的方法，而且简便、准确、快速。

OBJECTIVE:To determine minoxidil in minoxidil tincture and provide a methods of quality control.METHODS:Ultraviolet spectrometry was used.RESULTS:The method was linear within the range of 0.5 ～6 μg·ml -1 ( r = 0.999 9 , n =5).The recovery was 100.4 % with RSD of 1.0 %.CONCLUSIONS:The method is simple,quick and accurate for simultaneous determination of minoxidil in tincture.