乳腺癌危险因素的病例对照研究

Case-control Study on the Risk Factors of Breast Cancer

目的调查滕州市女性乳腺癌危险因素,为确定高危人群、制定干预措施提供依据。方法选择滕州市2007年1月—2009年5月期间,经病理学证实的102例乳腺癌患者,进行1∶1的病例对照研究,用SPSS12.0软件进行单因素和多因素logistic分析。结果经多因素非条件logistic回归分析,最终进入模型的因素为乳腺良性疾病史、不良性格、流产史、月经初潮年龄及哺乳史,其OR值分别为3.411,2.479,1.751,0.725和0.282。结论乳腺良性疾病史、不良性格、流产史、月经初潮年龄小的人群易患乳腺癌,母乳喂养是乳腺癌发病的保护性因素。

[Objective]To investigate the risk factors of female breast cancer in Tengzhou city,provide the evidences for determining the high risk population and making the intervention measures.[Methods]102 patients with breast cancer confirmed by pathology from January 2007 to May 2009 in Tengzhou were selected,1∶ 1 matched case-control study was conducted,and the data were analyzed with univariate and multivariate logistic regression by SPSS12. 0 software.[Results]The results of multivariate non-conditional logistic regression analysis showed that the major relevant factors were history of benign breast disease,bad character,abortion,age of menarche and nursing history,the OR values were 3. 411,2. 479,1. 751,0. 725 and 0. 282 respectively.[Conclusion]The people with history of benign breast disease,bad character,abortion history and younger menarche have high risk of breast cancer,and the breast feeding is protective factor for breast cancer.