谷胱甘肽S转移酶在乳腺癌中的表达

The GSTπexpression in breast carcinoma

目的探讨谷胱甘肽转移酶(GST-π)在乳腺癌组织中的表达状况及临床意义。方法采用SP免疫组织化学技术,检测36例乳腺癌组织、40例乳腺良性肿瘤组织中GST-π的表达情况。结果 GST-π在乳腺良性肿瘤中阳性表达率为22.5%(9/40),在乳腺癌中阳性表达率为69.44%(25/36),Ⅲ期乳腺癌中GST-π阳性表达率明显高于Ⅰ、Ⅱ期(P<0.05),淋巴结转移组GST-π阳性表达率明显高于无淋巴结转移组(P<0.05)。结论 GST-π阳性表达可能在乳腺癌的发生和发展过程中起重要作用,并影响其预后。

Objective To investigate the expression of GST-π in breast carcinoma and its biological values.Methods Streptavidin peroxidase conjugated method was used to detect the expression of GST-πin 36 cases of breast carcinoma and 40 cases of benign breast tumor.Results The positive rate of GST-π was 22.5%（9/40）in benign breast tumors and that in breast carcinoma was 69.44%（25/36）.The expression of GST-πin clinical stage Ⅲ was higher than that in stage Ⅰ,Ⅱ（P0.05）.The expression of GST-πin lymph node metastasis was higher than that no lymph node metastasis（P0.05）.Conclusions The positive expressions of GST-πin breast carcinoma may play an important role in the tumorigenesis and influences the prognosis of breast carcinoma.