参参康心滴丸对急性心肌缺血大鼠心电图及血清NO,血浆ET与心肌TNF-α,IL-6含量的影响

Effect of Shenshen Kangxin Drop Pills on ECG,Blood NO and ET,Myocardium TNF-α and IL-6 in Myocardial Ischemia of Rat

目的:观察参参康心滴丸对急性心肌缺血模型大鼠心电图ST段变化及血清一氧化氮(NO)、血浆内皮素(ET)与心肌组织肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)含量的影响,探讨其防治心肌缺血的作用及其机制。方法:ip盐酸异丙肾上腺素(ISO)复制急性心肌缺血大鼠模型,连续ig参参康心滴丸7 d后,记录心电图,然后取血及心肌组织,测量血清NO,血浆ET与心肌组织TNF-α,IL-6含量。结果:阳性对照组和参参康心药物各组ST段抬高值均降低,NO含量均有不同程度的升高,ET含量均降低,高剂量组TNF-α含量明显降低,高剂量组和阳性对照组IL-6含量明显降低。结论:参参康心滴丸改善急性心肌缺血的作用可能与升高血清NO含量及降低血浆ET及心肌组织TNF-α,IL-6含量有关。

Objective：To investigate the therapeutic action and mechanism of Shenshen Kangxin Drop Pills on the Myocardial Ischemia through observing the diversification of ECG of Myocardial Ischemia,blood NO and ET,myocardium TNF-α and IL-6.Method： Acute myocardial ischemia of rat was esfablished by intravenous injection of ISO.Treatment of the droppills（ig） was givenfor 7 d,ECG waveform,NO in blood,ET in blood,TNF-α,IL-6 in myocardium were measured.Result：ST section of Shenshen Kangxin group（low dose,medium dose and high dose respectively） and Tongxinluo Pills group was lower obviously than that of model group.NO went up and ET went down in Shenshen Kangxin group（low dose,medium dose and high dose respectively） and Tongxinluo Pills group.TNF-α went down in Shenshen Kangxin high dose group.IL-6 went down in Shenshen Kangxin high dose group and Tongxinluo Pills group.Conclusion： Shenshen Kangxin Drop Pills can alleviate myocardum ischemia.It may be related to increast in NO and decrease in ET,TNF-α and IL-6.