芪苈强心胶囊对慢性收缩性心力衰竭患者心功能及血浆脑利钠肽水平的影响

Effect of Qili Qiangxin Capsule on Cardiac Function and Levels of Brain Natriuretic Peptide in Patients with Chronic Systolic Heart Failure

目的:观察芪苈强心胶囊对慢性收缩性心力衰竭(CHF)患者心功能及血浆脑利钠肽水平的影响。方法:100例病因不同的CHF患者随机分为2组,对照组48例患者给予抗心力衰竭的常规治疗,如限盐、休息,根据病情选用利尿剂、血管紧张素转化酶抑制剂、β受体阻滞剂、螺内酯、硝酸酯类药物等,必要时根据病情应用洋地黄、多巴酚丁胺等正性肌力药物、抗生素。芪苈强心组52例在对照组治疗基础上加服芪苈强心胶囊(4粒,每日3次)。疗程均为6个月。观察2组治疗前后临床疗效、左室舒张末内径(LVEDD)、左室射血分数(LVEF)、6 min步行距离、血浆脑利钠肽(BNP)等。结果:治疗6个月后,芪苈强心组总有效率显著高于对照组(P<0.05)。芪苈强心组LVEDD及BNP比治疗前及对照组显著减少(P<0.01及P<0.05)。芪苈强心组的LVEF、6 min步行距离比治疗前及对照组显著增加(P<0.01及P<0.05)。2组均未发现明显不良反应。结论:芪苈强心胶囊治疗,可增加CHF患者LVEF,改善左室功能,提高运动耐量,降低血浆BNP水平,且安全性好。

Objective：To observate the effect of Qili Qiangxin capsule on cardiac function and levels of brain natriuretic peptide in patients with chronic systolic heart failure（CHF）.Method： One hundred patients with different causes of CHF were randomly divided into 2 groups,control group 48 patients were treated with conventional antifailure therapy,such as salt restriction,rest,under the conditions used diuretics,angiotensin converting enzyme inhibitors,β receptor blockers,spironolactone,nitrates,etc.,if necessary,apply conditions digitalis,dobutamine inotropic drugs such as antibiotics.Qili Qiangxin group of 52 cases were treated by Qili Qiangxin capsule on the basis of control group,four pills once,three times a day.Treatment for 6 months.Clinical and left ventricular end diastolic diameter（LVEDD）,left ventricular ejection fraction（LVEF）,6 min walking distance,the serum B-type natriuretic peptide（BNP） and other in two groups were observed before and after treatment.Result： After 6 months,the total effective rate of Qili Qiangxin group was significantly higher than that of the control group（P 〈 0.05）.LVEDD and BNP of Qili Qiangxin group were significantly decreased more than before treatment and that of the control group（P 〈 0.01 and P 〈 0.05）.LVEF,6 min walk distance of Qili Qiangxin group were significantly increased more than before treatment and that of the control group（P 〈 0.01 and P 〈 0.05）.The side effects were not found in both groups.Conclusion： CHF patients in the conventional therapy were added Qili Qiangxin capsule,increased LVEF,improvement of left ventricular function,exercise tolerance,decrease plasma BNP levels,and good security.