通塞益脑口服液质量标准研究

Study on Quality Standard of Tongsaiyinao Oral Liquid

目的:建立通塞益脑口服液的质量控制方法。方法:采用TLC法鉴别方中的地龙、川芎、延胡索;采用HPLC法测定通塞益脑口服液中阿魏酸含量。结果:在TLC色谱中可检出川芎、地龙、延胡索的特征成分斑点;阿魏酸在15.28～152.8mg·L-1呈良好的线性关系(r=0.999 7),平均加样回收率为99.38%(RSD 1.11%,n=6)。结论:所建立的方法能够准确可靠的进行定性、定量检测,重复性好,可作为通塞益脑口服液的质量控制标准。

Objective： To establish a method for the quality control of the Tongsaiyinao Oral Liquid.Method： TLC method was used to identify Dilong,Chuanxiong,and Yuanhu.HPLC was adopted to determine the ferulic acid in Chuanxiong.Result： The characteristic spots of these crude drugs could be detected in TLC color spectrum.Ferulic acid was linear in the range of 15.28-152.80 mg.L-1.The average recovery was 99.38% RSD 1.11%（n = 6）.Conclusion：The method was accurate and reliable with good reproducibility,and can be used as a quality control of Tongsaiyinao Oral Liquid.