老年病房下呼吸道分离鲍氏不动杆菌株的耐药性分析

Antibiotic Resistance of Acinetobacter baumannii Isolated from Lower Respiratory Tract of Patients in Department of Geriatrics

目的分析老年病房2006-2008年下呼吸道分离鲍氏不动杆菌株对临床常用抗菌药物的耐药特征,为临床用药提供参考。方法收集老年病房2006年1月-2008年12月住院患者下呼吸道分离的非重复鲍氏不动杆菌株,药敏试验采用K-B扩散法。结果 3年中共分离出178株鲍氏不动杆菌,除头孢哌酮/舒巴坦、亚胺培南的耐药率较低(5.6%～14.0%)外,其他抗菌药物的耐药率相对较高(30.9%～65.2%);亚胺培南耐药组及敏感组鲍氏不动杆菌对头孢哌酮/舒巴坦耐药率均最低,分别为24.0%和2.0%;≥四类药物的多药耐药株占33.1%。结论加强细菌及耐药性检测,掌握其耐药特征及流行规律,对于防治鲍氏不动杆菌的耐药及传播、控制老年病房的医院感染具有重要的现实意义。

OBJECTIVE To analyze the resistance profile of Acinetobacter baumannii isolated from lower respiratory tract in department of geriatrics for the purpose of guiding empirical therapy. METHODS Nonduplicate strains were isolated from Jan 2006 to Dec 2008 among elderly patients. K-B disk diffuse method was used in susceptibility testing. RESULTS AII the drug-sensitive test results of 178 bacteria in 3 years showed that drugresistance rate was relatively high （30. 9-65. 2%） except for cefoperazone-sulbactam （5. 6%） and imipenem （14.0 % ）; Both the imipenem-resistant strains and the imipenem-sensitive ones showed the lowest resistance rate to cefoperazone-sulbactam （24.0% and 2. 0%, respectively）; The ratio of multi-drug resistant A. baurnannii （MDR-AB） （resisted 4 or more kinds of antibiotic drugs） was 33. 1 %. CONCLUSIONS Preventing and reduceing the resistance and transmmision of A. baumannii, and controlling the nosocomial infection among elderly patients have realistic significance.