2007-2008年武汉儿童检验标本中分离鲍氏不动杆菌的耐药分析

Antibiotic Resistance of Acinetobacter baumannii Isolated from Children in Wuhan 2007-2008

目的了解武汉地区儿童分离鲍氏不动杆菌对常见抗菌药物的耐药性变迁。方法使用K-B法按统一方案进行抗菌药物敏感试验,χ2检验分析耐药性变化。结果 2007-2008年共分离鲍氏不动杆菌539株(分别为213、326株),新生儿内科分离率最高,2007年67株,分离率31.5%,2008年121株,分离率37.1%;与2007年相比,2008年分离菌对哌拉西林/他唑巴坦、头孢吡肟、头孢哌酮/舒巴坦、头孢他啶、亚胺培南、美罗培南的耐药率均显著增加(P<0.05)。结论 2008年武汉地区儿童分离鲍氏不动杆菌耐药性显著增长,但其耐药状况要明显好于成人分离株。

OBJECTIVE To investigate the variance of antibiotic resistance of Acinetobacter baumannii （ABA） isolated from children in Wuhan from 2007 to 2008. METHODS The antibacterial agents susceptibility test was carried out by using Kirby-Bauer method and the change in drug resistance was analyzed by X^2. RESULTS Totally 539 strains of ABA were isolated in 2007--2008 （213 and 326 strains of ABA separately）. The highest isoiated rate of ABA was observed in the department of neonate. The results of Chi-squared methods suggested that drug resistance rates of isolates of 2008 to ceftazidime, cefepime, piperacillin/sulbactam, cefoperazone/sulbactam, imipenem and meropenem be all increased significantly （P 〈 0. 05）, comparing to the results of 2007. CONCLUSIONS The drug resistaee of ABA isolated from children increases significantly in 2008, but the situation is distinctly better than that of adults.