妇科门诊女性生殖道人乳头状瘤病毒检测及感染调查分析

Status of Infection of Female Genitourinary Tract in Gynecology Clinic:HPV Detection and Investigation

目的了解温州地区妇科门诊女性生殖道人乳头状瘤病毒(HPV)感染状况,为宫颈癌的防治提供理论依据。方法采用导流杂交分型技术对2007年10月-2009年10月在妇科门诊就诊的1462例妇女进行生殖道21种HPV亚型感染检测。结果 1462例中HPV感染368例,总感染率为25.2%,高危型感染占16.2%,低危型占9.0%;21种亚型中除HPV44外,其他亚型均有检出,感染率最高的亚型是HPV16(6.7%),高危型中除HPV16外,HPV52、58、18和68型感染较多见;低危型以HPV6、11为主;HPV感染高峰年龄段在26～35岁(32.5%);不同年龄段、不同生殖道疾病患者HPV感染检出率差异均有统计学意义(P<0.01)。结论门诊高危人群HPV总感染率为25.2%,以高危型为主;高危型HPV感染与宫颈病变关系密切,因此,对门诊妇女有必要进行HPV感染筛查,对有高危型HPV感染人群,应定期随访和相应治疗,以降低宫颈癌的发病风险。

OBJECTIVE To investigate the infection status of human papillomavirus （HPV） of female genitourinary tract in gynecology clinic in Wenzhou City, and to provide theoretical basis for preventing and treating uterine cervical cancer. METHODS During Oct 2007 to Oct Z009,a total of 1462 outpatient women were checked for 21 HPV DNA types by DNA flow-through hybridization genotyping technique. RESULTS Among 1462 cases, 368 were infected with HPV,accounted for 25.2%. and the overall, prevalence of high-risk and low-risk HPV infection was 16.2% and 9. 0%. Among the 21 HPV DNA types of infection, HPV 44 was not detected. The highest infection rate of the high-risk types was HPV16. The other types,in descending order of frequency,were HPV52, 58,18 and 68, The major low risk HPV genotypes were 6, 11. The prevalence of HPV infection peaked from 25 years old to 35. There was significant difference of HPV infection among women with different ages and genitourinary tract diseases （P〈0. 01）. CONCLUSIONS The total infection rate is 25. 2% of HPV among high risk individuals of outpatients, mainly infected by of high-risk types, cervical diseases have close relationship to high-risk types infection. It should be very important to detect HPV-DNA in women and control the high-risk types HPV infection, to decrease in order the risk of cervical cancer.