摘要
目的为探讨Ⅰ期子宫内膜癌更为合理的治疗方案。方法将59例Ⅰ期子宫内膜癌患者随机分为两组:第1组30例,单纯全子宫、双附件切除加辅助治疗〔化、放疗和(或)激素治疗〕;第2组29例,行全子宫、双附件切除加盆腔淋巴结清扫或活检。结果第1组中死亡2例,2年和5年的存活率均为966%,平均生存697个月。第2组中死亡3例。2年存活率为957%,5年存活率为852%,平均生存439个月。这3例患者术后均未接受任何辅助治疗,发生远处器官或淋巴结转移后死亡。结论腹膜后淋巴结切除可明确分期,但不是Ⅰ期子宫内膜癌的治疗手段,Ⅰ期子宫内膜癌患者存在远处转移可能。是否所有Ⅰ期患者均应接受放射治疗,放射治疗对远处转移灶的效果,以及其它辅助性治疗如化疗药物的新配伍、新剂量和新方案等均有待于进一步探讨。
Objective\ Investigating the treatment for endometrial carcinoma stage I.Methods\ 59 women who had endometrial carcinoma stage I were divided into 2 groups randomly.30 patients were in group 1,who accepted the adjuvant therapy including chemo-,radio-and hormonotherapy after hysterectomy and bilateral salpingo-oophorectomy.The other 29 underwent the systematic retroperitoneal lymphadenectomy or retroperitoneal lymph nodes samplings.Results\ The 2-year and 5-year survival rate were both 96 6% in group 1 and 95 7% and 85 2% in group 2.There was no significant difference( P >0 05).4 of 5 dead patients were died of distant metastasis.Conclusions\ Retroperitoneal lymphadenectomy or retroperitoneal nodes biopsy play a more important role in diagnosis than in therapy in endometrial carcinoma stage I.The advanced discussion is to find the more effective therapy for distant metastasis.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1999年第4期219-221,共3页
Chinese Journal of Practical Gynecology and Obstetrics