卵巢克鲁根勃瘤p53蛋白表达的研究

Analysis and detection of the p53 expression in krukenbery's tumor

目的分析胃肠道粘液腺癌转移至卵巢后ｐ５３蛋白的表达。方法应用免疫组织化学ＢＳＡ法检测３２例卵巢的克鲁根勃瘤。结果阳性表达率４０９％（１３／３２），且以３０岁以下、双侧肿瘤术后存活期短患者为高表达，有统计学意义。结论ｐ５３蛋白作为独立因素影响卵巢克鲁根勃瘤的生物学行为和患者的预后。

Objective\ To study the significance of p53 expression in Krukenberg's tumor.Methods\ Using BSA immunohistochemical method.The p53 in 32 cases of Krukenberg's tumor was detected.Results\ The positive rate of p53 protein were 40 9%(13/32).The expression rate of p53 was high in the patients who were less than thirty years old,and had both sides tumors,and died in six months after operation.Conclusions\ The expression of were less than p53 protein is a factor which influences the biological behavior and prognosis of Krukenberg's tumor.