卵巢克鲁根勃瘤及卵巢癌P^(53)ER PR表达的研究

Analysis of the P^(53) Expression and Detecting ER,PR in Krukenberg's Tumor and Ovarian Cancer

应用免疫组织化学BSA法检测32例卵巢克鲁根勃瘤、20例卵巢癌中P53蛋白、雌激素受体（ER）、孕激素受体（PR），其阳性表达率克鲁根勃瘤分别10.9％（13／32）、21.9％（7／32）、21．9％（7／32），卵巢癌依次为45％（9／20）、65％（13／20）、50％（10／20）。结果表明P53在两者中阳性表达率无显著相关性，ER、PR在高分化卵巢癌中阳性表达率明显高于克鲁根勃瘤及低分化卵巢癌（P＜0．001）。在卵巢癌中ER、PR阳性表达率与组织学分化程度正相关（P＜0．05）与预后负相关（P＜0．01）。

Using BSA immunohistochemical methods, the P53 ER and PR in 32 cases of krukenberg's tumor and 20 cases of ovarian cancer were detected. The positive rate of P53 ER, PR in krukenberg's tumor and ovarian cancer were 40. 9% (13/32) Vs 45. 0% (9/20); 2l. 9% (7/32) Vs 65.0%(13/20) and 21. 9(7/20) Vs50% (10/20) respectively. There was no significant difference between krukenberg's tumor and ovarian cancer in the expression of P53,but the expression of ER and PR in high grade ovarian cancer was much higher than that in lower grade ovarian cancer and krukenberg's tumor. Expression of the ER and PR was correlated with differenciation and prognasis of the ovarian cancer.