摘要
目的:检测基质金属蛋白酶-2(MMP-2)和环氧化酶-2(Cox-2)在胃癌中的表达,并分析MMP-2、Cox-2的表达与胃癌淋巴结转移之间的关系。方法:以40例经病理确诊的胃癌组织为实验组,以20例正常胃黏膜为对照组,采用免疫组化法检测MMP-2和Cox-2蛋白的表达,并进行临床病理特点分析。结果:MMP-2、Cox-2蛋白在胃癌组织中表达的阳性率分别为67.5%和62.5%,二者之间呈正相关,MMP-2、Cox-2蛋白在TNMⅠ期表达阳性率分别为53.8%,61.5%;在Ⅱ期阳性率分别为57.1%、64.2%;在Ⅲ期阳性率分别为85.7%、85.7%;在Ⅳ期阳性率分别为100%(6/6),100%(6/6)。结论:MMP-2、Cox-2蛋白在胃癌中的表达明显增高,与肿瘤的淋巴结转移和TNM分期有关。检测胃癌组织MMP-2、Cox-2可作为判断胃癌浸润转移的重要指标。
Objective:To investigate the expression of matrix metalloproteinase-2 (MMP-2) and cyclo-oxygenase-2 (Cox-2) and its relationship with clinicopathological factors in gastric carcinoma.Methods:Forty specimens of gastric carcinoma tissues were confirmed pathologically and twenty specimens of gastric mucosa tissues were assessed by immunohistochemical method.Results:The positive immunohistochemical staining rates of MMP-2 and Cox-2 were 67.5% and 62.5%.Significant correlation between MMP-2 and Cox-2 was observed in gastric carcinoma tissues.The positive rates of MMP-2 and Cox-2 were 53.8% and 61.5% in TNM Ⅰ stage,57.1% and 64.2% in TNM Ⅱ stage,85.7% and 85.7% in TNM Ⅲ stage;and 100.0% in TNM Ⅳ stage.Conclusion:The expression of MMP-2 and Cox-2 is remarkably higher in gastric carcinoma tissues than in peri-carcinoma tissues and gastric mucosa tissues.There is positive correlation between the expression of MMP-2 and Cox-2.MMP-2 and Cox-2 can be used as indicators of invasion and metastasis of gastric carcinoma.
出处
《南通大学学报(医学版)》
2010年第5期319-321,324,F0002,共5页
Journal of Nantong University(Medical sciences)
关键词
胃癌
基质金属蛋白酶-2
环氧化酶-2
Gastric carcinoma
Matrix metalloproteinase-2
Cyclo-oxygenase-2