原发性肾病综合征患者抗心磷脂抗体的研究

Study on anticardiolipin antibody in the patients with primary nephrotic syndrome

检测６８例原发性肾病综合征和３０例正常人抗心磷脂抗体（Ａｃｌ抗体）。结果示：Ａｃｌ抗体阳性率分别为３２３５％和３３３％；阳性组的高凝状态及肾小球损伤比阴性组病人更为明显，且对治疗的敏感性也显著降低。提示Ａｃｌ抗体在原发性肾病综合征的发病及发展中可能有着重要的作用。

Combination of the anticardiolipin antibody with the phospholipids on the surfaces of the endothelia and thrombocytes can damage the basic functions of cells. In this study, the anticardiolipin antibody was detected in 68 cases with primary nephrotic syndrome and 30 healthy persons. The positive rates were 32.35% and 3.33%, respectively. The hypercoagulability and glomeralar impairment in the positive cases were more evident than those in the negative cases. In addition, the sensitivity to treatment in the positive cases was markedly decreased. These findings indicate that the anticardiolipin antibody may play an important role in pathophysiological processes of primary nephrotic syndrome.