慢性肾衰患者尿毒素对肠道细菌的作用

Urotoxic effect to intestinal bacteria in patients with chronic renal failure

取慢性肾衰病人和健康人粪便行需氧培养，并分别将其肠道大肠杆菌接种于肾衰病人血清培养基中培养，测定培养前后培养基中尿素氮、肌酐、尿酸量以观察细菌对以上尿毒素的降解作用。结果显示，慢性肾衰患者肠道大肠杆菌能明显降解尿素氮、肌酐、尿酸。

To analyse the differences of intestinal bacterial quality and quantity, the feces taken from chronic renal failure(CRF) and healthy subject were cultured aerobicly. Then the isolated E.coli from CRF patients and healthy subjects was inoculated respectively into cultural medium with CRF serum and incubated whose concentration of UN, Cr and UA in medium before and after incubation was measured to observe the bacteria degrade of the above mentioned urotoxin. Result: the intesinal E. coli can apparently degrade UN, Cr and UA in CRF patients which suggests that urotoxin may induce E. coli variation.