脓毒症研究的现状与展望

THE PRESENT AND PROSPECTS OF SEPSIS RESEARCH

脓毒症是严重创（烧）伤、休克、外科大手术后常见的并发症，进一步发展可导致脓毒性休克、多器官功能障碍综合征等，已成为临床危重患者的重要死亡原因之一。近年来，对脓毒症及其相关术语的含义给予了更新和发展，并达成共识。随着分子生物学的飞速发展及广泛应用，脓毒症发病机制研究日益加深。动物模型中脓毒症早期干预效果令人鼓舞，但其临床实验性治疗尚未能获得突破性进展。

Sepsis with subsequent septic shock and multiple organ dysfunction syndrome is the most common cause of mortality in the critically ill, including severe trauma, burns, hemorrhage, and major operations, etc. As a result of the American College of Chest Physicians/Society of Critical Care Medicine consensus conference held in August of 1991, standardized definitions of the syndromes of sepsis and organ dysfunction were proposed to assist clinicians and investigators to evaluate septic patients in research protocols and clinical trials. Despite considerable growth in our understanding of the potential mechanisms in sepsis and related complications, clinical trials conducted so far in human sepsis have not been so encouraging as animal studies.