黄原胶的流变学性质及助悬性能

Rheological properties of xanthan gum solution and its suspending effect

目的：测定黄原胶的流变学性质，考察其助悬性能。方法：在光照、冷冻（－１８℃）、冷藏（＋４℃）及辅料等因素影响下，采用ＮＤＪ－１型旋转粘度计测定黄原胶的流变学性质。以硫糖铝为模型药物，制备以黄原胶为助悬剂的１００ｇ·Ｌ－１硫糖铝混悬液。结果：黄原胶水溶液为塑性结构并具有触变性。其作为硫糖铝混悬剂时的最佳浓度为３ｇ·Ｌ－１，在此浓度下该混悬液具有显著触变性。结论：光照、冷冻（－１８℃）、冷藏（＋４℃）均不影响其流变学性质。该水溶液可作为药物助悬剂。

OBJECTIVE:To determine the rheological properties of xanthan gum and to investigate its suspending effect.METHODS:Under different conditions such as light,refrigeration and additives,the NDJ 1 rotative viscometry was used to measure the change of viscosity by various rates of shearing.We used sucralfate as model drug,xanthan gum as suspension agent,and prepared 100g·L -1 of sucralfate suspesion.RESULTS:Plastic construction and thixotropy appeared in the solutions.Its optimum concentration for suspension was 3g·L -1 and this suspension appeared significant thixotropy.CONCLUSION:Some factors such as light,refrigeration and additives have no effects on thixotropy.The solution of xanthan gum can be applied as suspension agent.