6Ting-Ming L,Alberman E,Swash M.Clinical features and associations of560cases of motor neurone disease. Journal of Neurology Neurosurgery and Psychiatry . 1990
7ImanmI,Gunniyi O.What is happening to motor neuron disease in Ni-geria. Annals of African Medicine . 2004
8Hristelina Ilieva,Magdalini Polymenidou,Don W.Cleveland.Non-cell autonomous toxicity in neurodegenerative disorders:ALS and be-yond. The Journal of Cell Biology . 2009
9Markus K,Melanie B,Peter B.Diagnostic problems and delay of di-agnosis in amyotrophic lateral sclerosis. Clinical Neurology and Neurosurgery . 2010
10Turner BJ,Talbot K.Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS. Progress in Neurobiology . 2008
3Jiang YM,Yamamoto M,Kobayashi Y,et al.Gene expression profile of spinal motor neurons insporadic amyotrophic lateral sclerosis.Ann Neurol,2005,57:236~251
4Zhang RZ,Gascon R,Miller RG,et a1.Evidence for systemic immune system alterations in sporadic amyotrophic lateralsclerosis(sALS).J Neuroimmunol,2005,156:215~224
5Sandri M,Sandri C,Gilbert A,et a1.Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.Cell,2004,117:399~412
6McGurire V,Longstreth WT,Koepsell TD,et al.Incidence Ofamyotrophic lateral sclerosis in three counties in western washington state.Neurology,1996,47:571~573
7Brooks BR,Miller RG,Swash M,etal.El Escorial revisited:Revised criteria for the diagnosis of amyotrophic lateral sclerosis.ALS and other motorn euron diorders,2000,1:293~299
8Gross-Paju K,Oopik M,Luus S-M,et al.Motor neurone disease in south Estonia.Diagnosis and incidence rate.Acta Neurol Scand,1998,98:22~28
9Rowland LP.Diagnosis of amyotrophic lateral sclerosis.J Neurol Sci,1998,160(suppl.1):S6~S24
10Ince PG,Evans J,Knopp M,et al.Corticospinal tract degeneration in the progression musclar atrophy variant of ALS.Neurology,2003,60:1252~1258