肝癌患者配偶及一级亲属乙肝病毒感染分析

Analysis of HBV infection in spouse and first degree relatives of PLC patients

目的:观察肝癌患者配偶、一级亲属乙肝病毒(HBV)感染情况。方法:检测139对肝癌患者和配偶及110例一级亲属HB-VM并对照分析。结果:肝癌配偶组HBVM阳性检出率显著低于肝癌组和肝癌一级亲属组(P<0.01);肝癌配偶组HbsAb阳性率较高(35.97%);肝癌患者及一级亲属HBVM最常见模式是HbsAg、HbeAb、HbcAb同时阳性。结论:肝癌患者及其一级亲属是一组HBV易感人群;肝癌患者配偶这一特殊人群不会因与肝癌家庭有密切接触而更易感染HBV。

Objective：To observe the distribution of HBV infection in the spouse and first degree relatives of the patients with primary liver cancer（PLC）.Methods：The serum markers of hepatitis B virus（HBVM） were tested in 139 patients with PLC and their spouses and first degree relatives.A matched case-control study was carried out.Results：The positive rate of HBVM in the spouses of PLC patients was significantly lower than that of PLC patients and their first degree relatives（P0.01）.The positive rate of anti-HBs in the spouses of PLC patients was higher（35.97%）.The most common type of HBVM was the positive of HBsAg,anti-HBe and anti-HBc simultaneously in PLC patients and their first degree relatives attacked by HBV.Conclusion：PLC patients and their first degree relatives are a susceptible group of HBV infection.The spouses of PLC patients,who are considered as a special crowd,can not infect with the HBV easier,because of close contact with PLC family.