COX-2和CD44v6在子宫内膜癌中的表达及其意义

Expression of COX-2 and CD44v6 in endometrial cancer and their significance

目的研究子宫内膜癌组织中COX-2和CD44v6的表达及其意义。方法采用免疫组织化学染色法检测46例子宫内膜癌组织中COX-2与CD44v6的表达情况,分析其相互关系及与子宫内膜癌临床病理学特征间的联系。结果子宫内膜癌组织中COX-2的阳性表达率为54.3%,淋巴结转移阳性者COX-2表达明显高于阴性者,而与患者年龄、临床分期和病理组织学分级无关。CD44v6的阳性表达率为67.4%,淋巴结转移阳性者明显高于阴性者,而与患者年龄、临床分期、病理组织学分级无关。在CD44v6表达阳性的子宫内膜癌患者中,COX-2表达阳性率为67.7%,而CD44v6表达阴性的子宫内膜癌患者中,COX-2阳性表达率为26.7%,两者相比差异有显著性(P<0.01)。结论子宫内膜癌组织中存在COX-2和CD44v6的表达,且两者成正相关,提示COX-2与CD44v6在子宫内膜癌组织中存在相互调控机制,共同促进肿瘤的发生、发展、浸润和转移。

【Objective】To investigate the expression and significance of cyclooxygenase-2（COX-2） and CD44v6 in endometrial cancer.【Methods】The expression of COX-2 and CD44v6 in 46 endometrial cancer patients were detected with immunohistochemical examination.The relationship between their expression and the clinicopathological features of endometrial adenocarcinoma was analyzed.【Results】The positive rate of COX-2 was 54.3%（25/46） in endometrial cancer,the expression was higher in patients with lymph node metastasis,but was not related with the ages,the clinical stages and the pathologic types.The expression rate of CD44v6 was 67.4%（31/46）,the expression was significantly higher in patients with lymph node metastasis,but was not related with the ages,the clinical stages and the pathologic types.COX-2 was positive in 67.70%（21/31） of CD44v6 positive patients and in 26.7%（4/15） of CD44v6 negative patients.There was a significant difference between the two figures（P〈0.01）.【Conclusions】 There is high expression of COX-2 and CD44v6 in endometrial cancer and they are positively correlated,which suggest that they may regulate each other and jointly contribute to the development,invasion and metastasis of endometrial cancer.