原发灶复发鼻咽癌再分期与预后的关系

Relationship Between Re-staging and Prognosis for Locally Recurrent Nasopharyngeal Carcinoma

[目的]探讨原发灶复发鼻咽癌的再分期与其预后的关系。[方法]对336例原发灶复发鼻咽癌患者的临床资料进行回顾性分析,采用UICC(2009)分期标准进行临床分期,应用Kaplan-Meier和Log-rank法计算和比较各期患者生存率。用Cox逐步回归模型进行多因素分析。[结果]全组患者1、3、5年生存率分别为85.0%、48.0%、32.0%,其中Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期的5年生存率分别为67.7%,35.0%,30.3%和19.9%,4组生存率比较差异有显著性(χ2=26.381,P=0.000)。Cox多因素分析结果显示临床分期是影响预后的因素。[结论]UICC(2009)分期可较好预测原发灶复发鼻咽癌的预后。

[Purpose] To investigate the relationship between re-staging and prognosis for locally recurrent nasopharyngeal carcinoma(rNPC).[Methods] Data of 336 cases with locally rNPC were analyzed retrospectively.Re-staging for the patients based on UICC(2009) staging system.Kaplan-Meier and Log-rank methods were used to calculate and compare the survival rate and multivariate analysis was performed with Cox model.[Results] The 1,3,5-year overall survival rates were 85.0%,48.0%,32.0% respectively.The 5-year overall survival rates of stage Ⅰ,Ⅱ,Ⅲ,Ⅳ were 67.7%,35.0%,30.3%,19.9% respectively,with significant difference in the four groups(χ2=26.381,P=0.000).Cox multivariated analysis showed that clinical stage was an important prognostic factor for survival rate.[Conclusion] TheUICC(2009)stagingsystem maypredicttheprognosisforlocally rNPC.