^(99m)Tc-MIBI肺亲肿瘤显像与肿瘤标志物联合诊断肺部结节良恶性的临床价值

The lung tumor imaging of ^(99m)Tc-MIBI combined with tumor markers in diagnosing pulmonary nodules

目的探讨99mTc-MIBI肺亲肿瘤显像与肿瘤标志物联合诊断肺部结节良、恶性的临床价值。方法对54例CT发现肺部结节的患者行99mTc-MIBI肺亲肿瘤显像与肿瘤标志物测定(包括NSE、CYFRA21-1,采用放射免疫法测定),分别计算出以上2种方法以及联合应用在诊断肺部结节中的灵敏度、特异性、准确性,通过统计学方法将联合应用后的结果分别与单一方法进行比较分析。结果①两种方法联合使用与单用99mTc-MIBI肺亲肿瘤显像相比,灵敏度、特异性、准确性均提高(P<0.05)。②两种方法联合使用与单用肿瘤标志物相比,灵敏度、准确性均提高(P<0.05),而特异性比较差异无统计学意义。结论 99mTc-MIBI肺亲肿瘤显像与肿瘤标志物测定两种方法联合使用在肺部结节良、恶性鉴别诊断中的价值要高于单一应用。

Objective To discuss the clinical value of 99m↑Tc-MIBI lung tumor-imaging combined with tumor markers to detect benign and malignant pulmonary nodules.Methods Fifty-four patients who were detected pulmonary nodules by the X-ray computed tomography were researched,and all of them underwent the lung tumor imaging of 99m↑Tc-MIBI,the detection of serum tumor markers（include NSE and CYFRA211,detected by RIA）,calculated separately the sensitivity,specificity and accuracy,then combined two methods to diagnose the pulmonary nodules,calculated the sensitivity,specificity and accuracy,to determine the clinical value of joint detection.Results ①Two methods in combination compared with a single detection of 99m↑Tc-MIBI lung tumor-imaging,its sensitivity,specificity and accuracy have significantly increased（P〈0.05）.②Two methods in combination compared with a single detection of serum tumor markers,its sensitivity and accuracy have significantly increased（P〈0.05）,but the specificity had no significant difference.Conclusion 99m↑Tc-MIBI lung tumor-imaging and tumor markers in the joint determination of two kinds of methods used in the pulmonary nodules benign and malignant differential diagnosis than any single application of one of the above.