低剂量沙利度胺治疗多发性骨髓瘤的疗效分析

Analysis of curative effects on multiple myeloma using low dose of thalidomide and chemotherapy

目的观察低剂量沙利度胺联合化疗治疗多发性骨髓瘤(MM)的疗效及不良反应。方法分析22例初治和8例复发难治MM患者应用低剂量沙利度胺联合化疗治疗的总有效率和不良反应;分析治疗前后患者M蛋白量、骨髓浆细胞比例以及血红蛋白浓度变化情况。结果 30例MM,完全缓解7例,部分缓解7例,微小反应4例,总有效率60%。治疗前后患者M蛋白量、骨髓浆细胞比例以及血红蛋白浓度相比差异有统计学意义(P<0.05)。应用沙利度胺不良反应轻,均可耐受。结论低剂量沙利度胺联合化疗治疗多发性骨髓瘤安全有效。

Objective To study the curative effects and adverse effects of the thalidomide combined with chemotherapy in treating multiple myeloma（MM）.Methods Twenty-two patients were initially diagnosised as MM and 8 patients were refractory and relapsed MM who were used low dose of thalidomide combined with chemotherapy.Complete response（CR）,partial response（PR）,minimal response（MR） and adverse effects were observed.Changes of M-protein in serum,percentage of plasma cells in bone marrow and the level of hemoglobin were also analyzed in pre-treatment and post-treatment periods.Results Among 30 patients the overall response rate（CR＋PR＋MR）was 60%,with 7 CR,7 PR,4 MR.Statistical significance was present between changes in pre-treatment and post-treatment periods.Adverse effects were less and tolerated.Conclusion Treatment of low dose of thalidomide combined with chemotherapy could significantly improve the effective rate with less adverse effect.